Myc Target in Myeloid Cells-1, a Novel c-Myc Target, Recapitulates Multiple c-Myc Phenotypes
نویسندگان
چکیده
منابع مشابه
C-Myc-independent restoration of multiple phenotypes by two C-Myc target genes with overlapping functions.
C-MYC, a transforming oncogene that is frequently overexpressed in many human cancers, regulates a variety of normal functions including cell cycle progression, apoptosis, and maintenance of cell size, morphology, and genomic integrity. Many target genes are modulated by c-Myc, and some can recapitulate a limited number of the above functions. Because most of these have been assessed in cells w...
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The product of the imprinted gene paternally expressed gene-10 (PEG10) has been reported to support proliferation in hepatocellular carcinomas, but how this gene is regulated has been an open question. We find that MYC knockdown by RNA interference suppresses PEG10 expression in Panc1 pancreatic carcinoma and HepG2 hepatocellular carcinoma cells and that knockdown of PEG10 inhibits the prolifer...
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the BM, because fewer somatic mutations were detected in immunoglobulin variable genes of CD19 2 PCs than in CD19 1 PCs, implying that these PC subsets arise at different times from different precursors during the evolution of the GC response. Remarkably, despite comparable expression of CD20 by CD19 1 and CD19 2 BMPCs, only CD19 1 BMPCs were reduced by therapeutic B-cell depletion with rituxim...
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c-Myc (Myc) is a regulator gene coding for a transcription factor. The c-Myc protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The mutated c-Myc is found in many cancers, which makes it be persistently expressed. This causes to the unregulated expression of many genes, some of which are involved in cell proli...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m200860200